Low-density lipoprotein and aortic stenosis

Statins and aortic stenosis in the context of ratio of low- to high-density lipoprotein cholesterol.

ischemia. With the increasing awareness of the mismatch between ischemia (MPI) and atherosclerosis/stenosis (MSCT and invasive angiography), one may even question the use of lesions on angiography as the gold standard. The second issue the authors raise concerns our statement that in patients with abnormal MPI revascularization may be indicated. We fully agree with the authors that clinical pre...

Oxidized Low Density Lipoprotein, Statin Therapy and Carotid Stenosis

The association between small dense low density lipoprotein,apolipoprotein B, apolipoprotein B/apolipoprotein A1 ratio and coronary artery stenosis

  Abstract   Background: Recently, small dense low density lipoprotein (sdLDL) has been   highlighted as a new risk factor for the coronary artery disease (CAD).Small dense   LDLs are believed to be atherogenic since these particles are taken up more easily by   arterial wall. They are readily oxidized and have reduced affinity for low density   lipoprotein (LDL) receptor and increased affinity...

Low-gradient aortic stenosis

Low-gradient aortic stenosis (AS) has been a vexing problem for cardiologists since its original description in 1980 by Carabello et al.1 In that study, 3 of 4 patients with low-gradient AS died at surgery, and the other patient had persistent severe heart failure postoperatively. Subsequent studies showed that although operative mortality is high, most patients survive aortic valve replacement...

Role of the low density lipoprotein receptor in penetration of low density lipoprotein into rabbit aortic wall.

The present study was designed to determine whether binding of low density lipoprotein (LDL) to endothelial LDL receptors contributes significantly to the penetration of LDL into the normal rabbit aorta. Initial flux rate was used as a measure of uptake of LDL. Reductive methylation of LDL is known to block its recognition by the LDL receptor. Therefore, the difference in flux rates of native L...